5-Aminoisoxazole → HCID 136332424, compound

HRID 1521789Notes

Reaction equation

HRID 1521789 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](/[CH:12]=[C:13](/[C:16](=O)[CH3:17])\[C:14]#[N:15])[CH:10]=2)[NH:5][N:4]=1.[O:19]1[C:23]([NH2:24])=[CH:22][CH:21]=[N:20]1>>[CH3:1][O:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:12]3[C:13]([C:14]#[N:15])=[C:16]([CH3:17])[NH:24][C:23]4[O:19][N:20]=[CH:21][C:22]3=4)[CH:10]=2)[NH:5][N:4]=1

Participants

3

Reactant 2

HCID 845915-AminoisoxazoleHCID 70494998HCID 70494998, compound

Product 1

HCID 136332424HCID 136332424, compound

Procedure

43 mg (0.178 mmol) (2E)-2-[(3-methoxy-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile (Example 8A) were treated with 1,2-oxazol-5-amine following the procedure described in Example 2. The crude material was purified by preparative RP-HPLC (acetonitrile/water gradient) to yield 3 mg (5% of th.) of the racemic title compound.

Workup

  1. customThe crude material was purified by preparative RP-HPLC (acetonitrile/water gradient)

Sources & evidence

ORD record
ord-0f79d40410dc4ece861abc596209313b
Source dataset
uspto-grants-2015_07
Patent number
US09073939B2

Reaction notes

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