HCID 89740138, compound → HCID 89740004, compound

Participants

Reaction Conditions

Reaction Steps

1-(7-bromo-4,5-dihydronaphtho[1,2-b]thiophen-2-yl) ethanone (11b) (600 mg, 1.95 mmol) was dissolved in 20 ml toluene and manganese dioxide (943 mg, 9.77 mmol) was added and the mixture was heated at 100° C. for 26 hr. Aliquots were taken in between to check the progress of the reaction by HPLC. Once the reaction was complete, the mixture was filtered over a pad of celite, and the celite pad was washed with ethyl acetate. The ethyl acetate layer was concentrated to obtain the desired compound (11c) (0.51 g, 85%). m/z 304, 306 (M+H)+.

Provenance & Evidence