HCID 66579130, compound → HCID 68228763, compound

HRID 1521838Notes

Reaction equation

HRID 1521838 reaction equation
[O-][N+:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[C:12]3[C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=4[S:19](=[O:22])(=[O:21])[CH2:20][C:11]=3[C:10]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[N:9]2)[CH:3]=1>C(OC(=O)C)(=O)C>[C:23]([O:25][CH2:26][C:7]1[N:2]=[CH:3][C:4]([N:8]2[C:12]3[C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=4[S:19](=[O:22])(=[O:21])[CH2:20][C:11]=3[C:10]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[N:9]2)=[CH:5][CH:6]=1)(=[O:24])[CH3:10]

Participants

3

Reactant 1

HCID 66579130HCID 66579130, compound

Product 1

HCID 68228763HCID 68228763, compoundYield 191.9%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of ethyl 1-(1-oxidopyridin-3-yl)-1,4-dihydrothiochromeno[4,3-c]pyrazole-3-carboxylate 5,5-dioxide (637 mg) in acetic anhydride (30 mL) is heated to 130° C. for 2 h under nitrogen. After completion of the reaction, the reaction mass is concentrated under reduced pressure and triturated in water, filtered and dried to afford 700 mg (99%) of the title compound. MS (ESI+): 442.0.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction mass is concentrated under reduced pressure
  3. customtriturated in water
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-654c69f88e7e48069514a1979f58d382
Source dataset
uspto-grants-2015_07
Patent number
US09073940B2

Reaction notes

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