Iodoethane → HCID 66580871, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(morpholin-4-ylcarbonyl)-2,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxide (0.400 g, 1.2 mmol) in acetonitrile (10 mL) is added potassium carbonate (0.49 g, 3.6 mmol) followed by ethyl iodide (0.56 g, 3.6 mmol). The reaction mixture is heated at 60° C. overnight. The crude reaction mixture is filtered through a celite pad and the filtrate concentrated under reduced pressure. The residue is purified by preparative HPLC to afford the title compound as an off-white solid. 1H NMR (DMSO-d6, 400 MHz): δ 8.02 (d, J=7.72 Hz, 1H), 7.94 (d, J=7.84 Hz, 1H), 7.89 (t, J=7.52 Hz, 1H), 7.72 (t, J=7.64 Hz, 1H), 4.79 (s, 2H), 4.57 (q, J=7.12 Hz, 2H), 3.94 (brs, 2H), 3.66-3.63 (m, 6H), 1.46 (t, J=7.16 Hz, 3H). MS (ESI+): 362.0. HPLC (max plot) 95.0%; Rt 2.99 min.

Provenance & Evidence