反应详情

To a solution of Example 11A (400 mg, 1.928 mmol) in dichloromethane (20 mL) was added pyridine (0.468 mL, 5.78 mmol) followed by benzoyl chloride (0.325 g, 2.314 mmol) and the mixture was stirred for 2 hours. The mixture was concentrated and the residue was dissolved in ethyl acetate, washed with sodium bicarbonate solution, water and brine, and dried over anhydrous sodium sulfate. Filtration, concentration and purification by column chromatography (silica gel, 10% ethyl acetate in hexane) afforded the title compound. LCMS: 311 (M+H)+.

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with sodium bicarbonate solution, water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationFiltration, concentration and purification by column chromatography (silica gel, 10% ethyl acetate in hexane)