Trifluoroacetic acid → HCID 90412514, compound

Participants

Reaction Steps

A solution of Example 137A (75 mg, 0.17 mmol) in dichloromethane (3 mL) was treated with trifluoroacetic acid (1 mL) for 10 minutes and was concentrated. The residue was purified by reverse phase HPLC, eluted with 10-70% acetonitrile in 0.1% trifluoroacetic acid/water to afford the title compound. LCMS: 333.11 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ 1.63-1.80 (m, 2H) 1.88 (d, 1H) 2.11 (d, 1H) 2.77-2.89 (m, 1H) 3.02-3.12 (m, 1H) 3.14-3.22 (m, 1H) 3.29 (d, 1H) 3.81 (s, 3H) 6.05 (d, 1H) 7.07 (d, 1H) 7.54 (s, 2H) 7.67 (s, 1H) 8.21 (d, 1H) 8.70 (d, 1H) 8.87 (s, 1H) 11.83 (s, 1H).

Provenance & Evidence