Tetrahydrofuran → HCID 90411156, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 212A (70 mg, 0.265 mmol) in 3 mL of N,N-dimethylformamide was treated with 1M tetra-n-butyl ammonium fluoride in tetrahydrofuran (0.531 mL, 0.531 mmol) and the mixture was heated at 65° C. for 12 hours. The mixture was poured into 30 mL 1:1 water/ethyl acetate and the organic layer was washed with water and brine, dried over sodium sulfate, filtered, and concentrated. Purification by column chromatography (silica, 5% ethyl acetate-hexane) afforded the title compound. LCMS: 236.8 (M+H)+.

Provenance & Evidence