Sodium Hydroxide → HCID 90411397, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 87B (4 g, 7.87 mmol) in 75 mL dioxane was added 6M aqueous sodium hydroxide (13.12 mL, 79 mmol). The mixture was heated at 100° C. for 1 hour, cooled, and reduced to half volume in vacuo. The residue was diluted with 50 mL ethyl acetate, washed with saturated sodium bicarbonate and brine, dried over magnesium sulfate, filtered, and concentrated to give the title compound. LCMS: 369.53 (M+H)+.

Provenance & Evidence