Water → HCID 90414070, compound

Participants

Reaction Steps

A solution of Example 229F (0.049 g, 0.137 mmol) and triethylamine (0.057 mL, 0.411 mmol) in N,N-dimethylformamide (1.4 mL) was treated with 2,5-dioxopyrrolidin-1-yl methylcarbamate (0.035 g, 0.205 mmol) and the mixture was stirred at room temperature for 16 hours. The mixture was poured into water and the solid was filtered and dried under vacuum to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ 2.32-2.43 (m, 2H), 2.58 (d, J=4.3 Hz, 3H), 3.46 (t, J=5.7 Hz, 2H), 3.70 (s, 3H), 3.96-4.03 (m, 2H), 6.01-6.08 (m, 1H), 6.40-6.47 (m, 1H), 6.47-6.55 (m, 1H), 7.14 (dd, J=8.6, 3.1 Hz, 1H), 7.20 (dd, J=9.2, 4.5 Hz, 1H), 7.26-7.39 (m, 1H), 8.24 (s, 1H), 12.03 (bs, 1H). MS (ESI+) m/z 415.1 (M+H)+.

Provenance & Evidence