HCID 90413388, compound → HCID 90413566, compound

Participants

Reaction Steps

A solution of Example 307B (50 mg, 0.09 mmol) in dichloromethane (5 mL) and trifluoroacetic acid (1 mL) was stirred for 15 minutes and concentrated. The residue was purified by reverse phase chromatography (C18 column) eluting with 10%-70% acetonitrile in 0.1% TFA water solution to provide the title compound. 1H NMR (400 MHz, DMSO-d6) δ 1.69-1.86 (m, 2H), 2.21 (d, 2H), 2.96-3.13 (m, 3H), 3.37 (d, 2H), 4.53 (s, 3H), 5.96 (s, 1H), 6.63 (s, 1H), 7.02 (d, 1H), 7.04-7.12 (m, 1H), 7.12-7.23 (m, 2H), 7.34-7.42 (m, 1H), 7.51 (s, 1H), 8.15 (s, 1H), 8.24 (d, 1H), 8.26-8.39 (m, 1H), 8.66 (d, 1H), 11.89 (s, 1H), LCMS: 436 (M+H)+.

Provenance & Evidence