Sulfuryl chloride → (3-Chloropropyl)sulfamyl chloride

HRID 1522061Notes

Reaction equation

HRID 1522061 reaction equation
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].Cl.[Cl:7][CH2:8][CH2:9][CH2:10][NH2:11]>C(#N)C>[Cl:7][CH2:8][CH2:9][CH2:10][NH:11][S:1]([Cl:5])(=[O:3])=[O:2]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 114690951-Propanamine, 3-chloro-, hydrochloride

Product 1

HCID 55279789(3-Chloropropyl)sulfamyl chloride

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To sulfuryl chloride (5 g, 30.05 mmol) in acetonitrile (30 mL), was added 3-chloropropyl amine hydrochloride (486 mg, 5.00 mmol). The reaction mixture was allowed to react at 80° C., evaporated and then extracted with diethyl ether and H2O, followed by evaporation of the organic layer under vacuum, to give 3-chloropropylsulfamoyl chloride that was used without further purification.

Workup

  1. customto react at 80° C.
  2. customevaporated
  3. extractionextracted with diethyl ether and H2O
  4. customfollowed by evaporation of the organic layer under vacuum

Sources & evidence

ORD record
ord-0faf6b744de745e4a72f7b590d19ef07
Source dataset
uspto-grants-2015_07
Patent number
US09073906B2

Reaction notes

Loading…