Triphenylphosphine → HCID 86708920, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-((N-(2,4,6-trichlorophenyl)sulfamoyl)amino)acetate (380 mg, 1.05 mmol), cyclopropane-1,1-diyldimethanol (107 mg, 1.05 mmol) and triphenylphosphine (689 mg, 2.63 mmol) were dissolved in anhydrous THF (30 mL) in a reactor, and then cooled down −20° C. after removal of air in the reactor by purging nitrogen gas. DIAD (532 mg, 2.63 mmol) was dropwisely added to the reaction mixture and agitated for 5 hr at room temperature. The resultant was concentrated under reduced pressure and purified by column chromatography (dichloromethane:hexane:ethyl acetate=5:4:1), finally yielding the title compound (198 mg, 44%, white solid). 1H NMR (300 MHz, CDCl3): δ 7.39 (s, 2H), 4.39 (s, 2H), 4.26-4.19 (q, 2H, J=7.1, 7.1, 7.1 Hz), 3.73 (s, 2H), 3.57 (s, 2H), 1.32-1.27 (t, 3H, J=7.1, 7.1 Hz), 0.66-0.64 (m, 4H).

Provenance & Evidence