Hydrochloric Acid → HCID 86708921, compound

Participants

Reaction Steps

To ethyl 2-(6,6-dioxido-7-(2,4,6-trichlorophenyl)-6-thia-5,7-diazaspiro[2,5]-octane-5-yl)acetate (60 mg, 0.14 mmol) in THF (5 mL) and MeOH (5 mL), was added LiOH monohydrate (25 mg, 0.58 mmol) in water (1 mL) and agitated for 5 hr at room temperature. After addition of ethyl acetate (30 mL) and water (30 mL), pH of the resultant was adjusted to 3 with 1 N HCl and extracted to the organic layer. The resultant was dried over MgSO4, concentrated under reduced pressure, and crystallized with ethyl acetate (1 mL) and hexane (10 mL), giving the compound of interest (50 mg, 89%, white solid). 1H NMR (300 MHz, CDCl3): δ 7.39 (s, 2H), 4.39 (s, 2H), 3.73 (s, 2H), 3.57 (s, 2H), 0.66-0.64 (m, 4H).

Provenance & Evidence