HCID 86708920, compound → HCID 86708922, compound

Participants

Reaction Steps

Ethyl 2-(6,6-dioxido-7-(2,4,6-trichlorophenyl)-6-thia-5,7-diazaspiro[2.5]-octane-5-yl)acetate (50 mg, 0.12 mmol) and Pt(IV)O2 (54 mg, 0.24 mmol) were dissolved in acetic acid (10 mL) in a reactor and then air in the reactor was removed by introducing hydrogen gas, followed by shaking for 14 hr under 50 psi. The resultant was washed with ethyl acetate and filtered over celite. To the filtrate, was added water (50 mL) and neutralized using 1 N NaOH, followed by extraction to obtain the organic layer. The resultant was dried over MgSO4, concentrated under reduced pressure, and purified by column chromatography (hexane:ethyl acetate=8:2), giving the compound of interest (46 mg, 77%, light apricot-colored solid). 1H NMR (300 MHz, CDCl3): δ 7.38 (s, 2H), 4.26-4.19 (q, 2H, J=7.1, 7.1, 7.1 Hz), 4.17 (s, 2H), 3.65 (s, 2H), 3.49 (s, 2H), 1.32-1.27 (t, 3H, J=7.1, 7.1 Hz), 1.22 (s, 6H).

Provenance & Evidence