Sulfuryl chloride → HCID 85805063, compound

HRID 1522076Notes

Reaction equation

HRID 1522076 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].[S:9](Cl)([Cl:12])(=[O:11])=[O:10]>CC#N>[Cl:12][S:9]([NH:7][CH2:6][C:5]([O:4][CH2:2][CH3:3])=[O:8])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 85805063HCID 85805063, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To glycine ethylester hydrochloride (5.00 g, 35.8 mmol) in CH3CN (200 mL), was added sulfuryl chloride (29.00 g, 214.8 mmol), refluxed for 12 hr, and concentrated under reduced pressure. To the reaction mixture, was diethyl ether (100 mL), concentrated under reduced pressure (2×), and dried under vacuum. The resultant was used without further purification.

Workup

  1. temperaturerefluxed for 12 hr
  2. concentrationconcentrated under reduced pressure
  3. concentrationconcentrated under reduced pressure (2×)
  4. customdried under vacuum
  5. customThe resultant was used without further purification

Sources & evidence

ORD record
ord-477adcee3e114780b9c6e29b6696e60d
Source dataset
uspto-grants-2015_07
Patent number
US09073906B2

Reaction notes

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