Hydrochloric Acid → HCID 86708933, compound

Participants

Reaction Steps

To ethyl 2-(4,4-difluoro-1,1-dioxido-6-(2,4,6-trichlorophenyl)-1,2,6-thiadiazinan-2-yl)acetate (40 mg, 0.10 mmol) in THF (10 mL) and MeOH (10 mL), was dropwisely added LiOH monohydrate (21 mg, 0.50 mmol) in water (3 mL) and agitated for 5 hr at room temperature. After addition of ethyl acetate (30 mL) and water (30 mL), pH of the resultant was adjusted to 3 with 1 N HCl and extracted to obtain the organic layer. The organic layer was dried over MgSO4, concentrated under reduced pressure, and crystallized with ethyl acetate (1 mL) and hexane (10 mL), giving the compound of interest (33 mg, 80%, white solid). 1H NMR (300 MHz, CDCl3): δ 7.44 (s, 2H), 4.35 (s, 2H), 4.14-4.03 (m, 4H).

Provenance & Evidence