Hydrochloric Acid → 5-(4-phenoxyphenyl)-N4-(2-azaspiro[3.3]heptan-6-yl)pyrimidine-4,6-diamine

Participants

Reaction Steps

In a round bottom flask containing 6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester (167.23 mg; 0.35 mmol; 1.00 eq.) in methanol (5.00 ml) was added hydrogen chloride (1.80 ml; 3.53 mmol; 10.00 eq.). The reaction was stirred for 16 h before it was concentrated and carried to the next step.

Provenance & Evidence