1-Boc-4-(aminomethyl)piperidine → HCID 71092817, compound

HRID 1522115Notes

Reaction equation

HRID 1522115 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20]C(C)(C)C)=O)[CH2:14][CH2:13]1.[O:25]([C:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[CH3:41][O:42][CH2:43][CH2:44][N:45]([CH3:52])[CH2:46]/[CH:47]=[CH:48]/C(O)=O>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([C:18](=[O:20])/[CH:48]=[CH:47]/[CH2:46][N:45]([CH2:44][CH2:43][O:42][CH3:41])[CH3:52])[CH2:16][CH2:17]2)[C:2]=1[C:29]1[CH:30]=[CH:31][C:26]([O:25][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:27][CH:28]=1

Participants

5

Reactant 4

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 27343774-Phenoxyphenylboronic acidHCID 21697328HCID 21697328, compoundHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 71092817HCID 71092817, compound

Procedure

(E)-1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)-4-((2-methoxyethyl)(methyl)amino)but-2-en-1-one was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, (4-phenoxyphenyl)boronic acid and (E)-4-((2-methoxyethyl)(methyl)amino)but-2-enoic acid using methods B, C, D, and E. HPLC purity: 99%. MS: m/z=531 [M+H]+.

Sources & evidence

ORD record
ord-42ae9ce161064262b6c54fd9606ebc3f
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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