Acryloyl chloride → HCID 71474223, compound

HRID 1522122Notes

Reaction equation

HRID 1522122 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])OC(C)(C)C.[O:21]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[C:37](Cl)(=O)[CH:38]=C>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[CH:37]=[CH2:38])[C:2]=1[C:25]1[CH:26]=[CH:27][C:22]([O:21][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:23][CH:24]=1

Participants

5

Reactant 4

HCID 13140Acryloyl chlorideHCID 187201N-BOC-ethylenediamineHCID 27343774-Phenoxyphenylboronic acidHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 71474223HCID 71474223, compound

Procedure

N-(2-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)ethyl)acrylamide was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl (2-aminoethyl)carbamate, (4-phenoxyphenyl)boronic acid, and acryloyl chloride using methods B, C, D, and F. HPLC purity: 100%. MS: m/z=376 [M+H]+.

Sources & evidence

ORD record
ord-2dfe71ac19434e609c3e42549dbeb32d
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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