Acryloyl chloride → HCID 71474280, compound

HRID 1522134Notes

Reaction equation

HRID 1522134 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20]C(C)(C)C)=O)[CH2:14][CH2:13]1.[CH2:25]([N:32]1[CH:36]=[C:35](B(O)O)[CH:34]=[N:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[C:40](Cl)(=O)[CH:41]=C>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([C:18](=[O:20])[CH:40]=[CH2:41])[CH2:16][CH2:17]2)[C:2]=1[C:35]1[CH:34]=[N:33][N:32]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:36]=1

Participants

5

Reactant 4

HCID 13140Acryloyl chlorideHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 33528811-Benzyl-1H-pyrazole-4-boronic acidHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 71474280HCID 71474280, compound

Procedure

1-(4-(((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, (1-benzyl-1H-pyrazol-4-yl)boronic acid, and acryloyl chloride using methods B, C, D, and F. HPLC purity: 100%. MS: m/z=418 [M+H]+.

Sources & evidence

ORD record
ord-d659c7408f914336bcdfadea8c8ec58f
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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