HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acryloyl chloride → HCID 71474334, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | 4-Phenoxyphenylboronic acid | HCID 2734377 | — |
| Reactant | tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate | HCID 21934652 | — |
| Reactant | 5,6-Dichloro-2-methylpyrimidin-4-amine | HCID 45480502 | — |
| Product | HCID 71474334 | HCID 71474334 | — |
Reaction Steps
1-(4-(((6-amino-2-methyl-5-(4-phenoxyphenyl)pyrimidin-4-yl)(methyl)amino)methyl)piperidin-1-yl)prop-2-en-1-one was prepared from 5,6-dichloro-2-methylpyrimidin-4-amine, tert-butyl 4-((methylamino)methyl)piperidine-1-carboxylate, (4-phenoxyphenyl)boronic acid, and acryloyl chloride using methods B, C, D, and F. HPLC purity: 100%. MS: m/z=458 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073947B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-830e99db54c9433ba31f3913661d0b7a |
| Source note | uspto-grants-2015_07 |