tert-butyl N-(4-aminobutyl)carbamate → HCID 86721762, compound

HRID 1522150Notes

Reaction equation

HRID 1522150 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[O:22])OC(C)(C)C.[O:23]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[C:39](Cl)(=O)[CH:40]=C>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[O:22])[CH:39]=[CH2:40])[C:2]=1[C:27]1[CH:28]=[CH:29][C:24]([O:23][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:25][CH:26]=1

Participants

5

Reactant 4

HCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 13140Acryloyl chlorideHCID 27343774-Phenoxyphenylboronic acidHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 86721762HCID 86721762, compound

Procedure

N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)butyl)acrylamide was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl (4-aminobutyl)carbamate, (4-phenoxyphenyl)boronic acid, and acryloyl chloride using methods B, C, D, and F. HPLC purity: 100%. MS: m/z=404 [M+H]+.

Sources & evidence

ORD record
ord-d27c916ccdd44891bc74e6ae3a86a965
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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