1-Boc-4-(aminomethyl)piperidine → HCID 86721765, compound

HRID 1522154Notes

Reaction equation

HRID 1522154 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1.[O:25]([C:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[C:41]1(/[CH:47]=[CH:48]/[S:49](Cl)(=[O:51])=[O:50])[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[O:25]([C:32]1[CH:37]=[CH:36][C:35]([C:2]2[C:7]([NH:10][CH2:11][CH:12]3[CH2:13][CH2:14][N:15]([S:49](/[CH:48]=[CH:47]/[C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)(=[O:51])=[O:50])[CH2:16][CH2:17]3)=[N:6][CH:5]=[N:4][C:3]=2[NH2:9])=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 4

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 27343774-Phenoxyphenylboronic acidHCID 5369377(E)-2-phenylethene-1-sulfonyl chlorideHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 86721765HCID 86721765, compound

Procedure

(E)-5-(4-phenoxyphenyl)-N4-((1-(styrylsulfonyl)piperidin-4-yl)methyl)pyrimidine-4,6-diamine was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, (4-phenoxyphenyl)boronic acid, and (E)-2-phenylethenesulfonyl chloride using methods B, C, D, G. HPLC purity: 98%. MS: m/z=542 [M+H]+.

Sources & evidence

ORD record
ord-a39a56e1c0fe4b7db0a3c70bc49ebfd5
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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