4-Phenoxyphenylboronic acid → HCID 71092815, compound

HRID 1522156Notes

Reaction equation

HRID 1522156 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][NH:15][C:14](=[O:18])[CH2:13]1.[O:19]([C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][C:14](=[O:18])[CH2:13]2)[C:2]=1[C:29]1[CH:30]=[CH:31][C:26]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:27][CH:28]=1

Participants

4

Reactant 3

HCID 27343774-Phenoxyphenylboronic acidHCID 242192625,6-Dichloro-pyrimidin-4-ylamineHCID 601502934-(Aminomethyl)-2-piperidinone

Product 1

HCID 71092815HCID 71092815, compound

Procedure

4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-2-one was prepared from 5,6-dichloropyrimidin-4-amine, 4-(aminomethyl)piperidin-2-one, (4-phenoxyphenyl)boronic acid using methods I, and C. HPLC purity: 100%. MS: m/z=390 [M+H]+.

Sources & evidence

ORD record
ord-b3acec2782db49b7a16f854bc0ecdbb1
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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