3-Aminophenol → HCID 71474390, compound

HRID 1522157Notes

Reaction equation

HRID 1522157 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][C:11]1[CH:12]=[C:13]([OH:17])[CH:14]=[CH:15][CH:16]=1.[O:18]([C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.Cl[CH2:35][CH2:36][S:37](Cl)(=[O:39])=[O:38]>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([O:17][C:13]2[CH:12]=[C:11]([NH:10][S:37]([CH:36]=[CH2:35])(=[O:39])=[O:38])[CH:16]=[CH:15][CH:14]=2)[C:2]=1[C:22]1[CH:23]=[CH:24][C:19]([O:18][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:20][CH:21]=1

Participants

5

Reactant 4

HCID 115683-AminophenolHCID 15385Ethanesulfonylchloride, 2-chloro-HCID 27343774-Phenoxyphenylboronic acidHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 71474390HCID 71474390, compound

Procedure

N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)phenyl)ethenesulfonamide was prepared from 5,6-dichloropyrimidin-4-amine, 3-aminophenol, (4-phenoxyphenyl)boronic acid, and 2-chloroethanesulfonyl chloride using methods A, C, and G. HPLC purity: 77%. MS: m/z=461 [M+H]+.

Sources & evidence

ORD record
ord-076e47c39ecf454bacf3bea1718b96b7
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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