Acryloyl chloride → HCID 86721766, compound

HRID 1522158Notes

Reaction equation

HRID 1522158 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:21])OC(C)(C)C.[O:22]([C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[C:38](Cl)(=O)[CH:39]=C>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:21])[CH:38]=[CH2:39])[C:2]=1[C:26]1[CH:27]=[CH:28][C:23]([O:22][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:24][CH:25]=1

Participants

5

Reactant 4

HCID 13140Acryloyl chlorideHCID 27343774-Phenoxyphenylboronic acidHCID 2735700tert-Butyl (3-aminopropyl)carbamateHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 86721766HCID 86721766, compound

Procedure

N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)propyl)acrylamide was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl (3-aminopropyl)carbamate, (4-phenoxyphenyl)boronic acid, and acryloyl chloride using methods B, C, D, and F. HPLC purity: 100%. MS: m/z=390 [M+H]+.

Sources & evidence

ORD record
ord-9875fc2fdde840d58c0e99bde547a958
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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