3-Aminophenol → N-(3-((6-amino-5-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)oxy)phenyl)acrylamide

참여 물질

역할	이름	HCID	투입량
반응물	3-Aminophenol	HCID 11568	—
반응물	Acryloyl chloride	HCID 13140	—
반응물	5,6-Dichloro-pyrimidin-4-ylamine	HCID 24219262	—
반응물	1-(4-methoxybenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 53440213	—
생성물	N-(3-((6-amino-5-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)oxy)phenyl)acrylamide	HCID 86721771	—

반응 단계

N-(3-((6-amino-5-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)oxy)phenyl)acrylamide was prepared from 5,6-dichloropyrimidin-4-amine, 3-aminophenol, 1-(4-methoxybenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, and acryloyl chloride using methods A, C, and F. HPLC purity: 99%. MS: m/z=443 [M+H]+. 1H-NMR (DMSO-d6) δ 10.21 (s, 1H), 8.08 (s, 1H), 8.01 (s, 1H), 7.70 (s, 1H), 7.50 (s, 1H), 7.41 (d, 1H), 7.33-7.26 (m, 3H), 6.90 (d, 2H), 6.83-6.58 (m, 2.5H), 6.40 (dd, 1H), 6.25 (d, 1H), 5.76 (d, 1H), 5.28 (s, 2H), 3.73 (s, 3H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09073947B2
출처 데이터셋	uspto-grants-2015_07
ORD ID	ord-9ef174e7d1e74dd79b41c33f74b82df1
출처 메모	uspto-grants-2015_07