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HRID1522167

反应详情

EQUATION

反应方程式

HRID 1522167 的结构方程式

REACTANTS

反应物

4
结构：C=CC(=O)Cl
HCID13140

Acrylyl chloride

C3H3ClO

结构：OB(O)c1ccc(Oc2ccccc2)cc1
HCID2734377

4-Phenoxyphenylboronic acid

C12H11BO3

结构：CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](O)C1
HCID11275699

未命名化合物

结构：Nc1ncnc(Cl)c1Cl
HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

PRODUCTS

生成物

1
结构：C=CC(=O)N1C[C@@H](O)[C@H](Nc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)C1
HCID89266698

未命名化合物

PROCEDURE

实验过程

1-(trans-3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)-4-hydroxypyrrolidin-1-yl)prop-2-en-1-one was prepared from 5,6-dichloropyrimidin-4-amine, trans-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate, (4-phenoxyphenyl)boronic acid, and acryloyl chloride using methods B, C, D, and F. HPLC purity: 100%. MS: m/z=418 [M+H]+.