Acryloyl chloride → HCID 86721778, compound

HRID 1522174Notes

Reaction equation

HRID 1522174 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[NH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20]C(C)(C)C)=O)[CH2:14][CH2:13]1.[CH3:25][O:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34].[C:40](Cl)(=O)[CH:41]=C>>[NH2:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([C:18](=[O:20])[CH:40]=[CH2:41])[CH2:16][CH2:17]2)[C:2]=1[C:29]1[CH:28]=[C:27]([O:26][CH3:25])[C:32]([O:33][CH3:34])=[C:31]([O:35][CH3:36])[CH:30]=1

Participants

5

Reactant 4

HCID 13140Acryloyl chlorideHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 27343903,4,5-Trimethoxybenzeneboronic acidHCID 242192625,6-Dichloro-pyrimidin-4-ylamine

Product 1

HCID 86721778HCID 86721778, compound

Procedure

1-(4-(((6-amino-5-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, (3,4,5-trimethoxyphenyl)boronic acid, and acryloyl chloride in four steps according to general scheme 2, using methods I, C, D and G. MS: m/z=428 [M+H]+. 1H-NMR (400 MHz, DMSO-d6): δ 8.34 (s, 1H), 7.17 (s, 1H), 6.99 (s, 2H), 6.79 (dd, 1H), 6.57 (s, 2H), 6.07 (dd, 1H), 5.65 (dd, 1H), 4.37 (d, 1H), 4.02 (d, 1H), 3.79 (s, 6H), 3.76 (s, 3H), 3.25 (bs, 2H), 2.99 (t, 1H), 2.59 (t, 1H), 1.85 (bs, 1H), 1.65 (d, 2H), 1.09-0.90 (m, 2H).

Sources & evidence

ORD record
ord-885ac56a9b4340d99c048ca0978232d7
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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