Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propiolic Acid → 1-(6-((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-2-azaspiro[3.3]heptan-2-yl)prop-2-yn-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propiolic Acid | HCID 10110 | — |
| 반응물 | 1-Benzyl-1H-pyrazole-4-boronic acid | HCID 3352881 | — |
| 반응물 | 5,6-Dichloro-pyrimidin-4-ylamine | HCID 24219262 | — |
| 반응물 | tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate | HCID 46930560 | — |
| 생성물 | 1-(6-((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-2-azaspiro[3.3]heptan-2-yl)prop-2-yn-1-one | HCID 86721797 | — |
반응 단계
1-(6-((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-2-azaspiro[3.3]heptan-2-yl)prop-2-yn-1-one was prepared from 5,6-dichloropyrimidin-4-amine, (1-benzyl-1H-pyrazol-4-yl)boronic acid, tert-butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate and propiolic acid according to general scheme 3 using methods S1, S2, S3, and S4A. HPLC purity: 95%. MS: m/z=414 [M+H]+. 1H NMR (CD3OD) δ 8.21 (s, 1H), 7.83 (s, 1H), 7.57 (s, 1H), 7.41 (m, 5H), 5.42 (s, 2H), 4.54 (s, 1H), 4.31 (d, 2H), 4.08 (d, 2H), 3.88 (d, 1H), 2.61 (m, 2H), 2.30 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09073947B2 |
| 출처 데이터셋 | uspto-grants-2015_07 |
| ORD ID | ord-cc2cbba8debd4ceeb5dc4b5697162f72 |
| 출처 메모 | uspto-grants-2015_07 |