Acryloyl chloride → HCID 86721813, compound

Participants

Role	Name	HCID	Charge
Reactant	Acryloyl chloride	HCID 13140	—
Reactant	1-Boc-4-(aminomethyl)piperidine	HCID 736817	—
Reactant	5,6-Dichloro-pyrimidin-4-ylamine	HCID 24219262	—
Reactant	N-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide	HCID 57415689	—
Product	HCID 86721813	HCID 86721813	—

Reaction Steps

4-(4-(((1-acryloylpiperidin-4-yl)methyl)amino)-6-aminopyrimidin-5-yl)-N-phenylbenzamide was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, N-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide and acryloylchloride using methods B, C, D and F. HPLC: 99%. MS: m/z=457 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09073947B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-7ac787fb13154e26a3ed866b6e35bd5a
Source note	uspto-grants-2015_07