Acryloyl chloride → HCID 178460243, compound

HRID 1522223Notes

Reaction equation

HRID 1522223 reaction equation
Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.C(O[C:15](=[O:24])[NH:16][C@H:17]1[CH2:22][CH2:21][C@@H:20]([NH2:23])[CH2:19][CH2:18]1)(C)(C)C.[C:25]1([NH:31][C:32](=[O:48])[C:33]2[CH:38]=[CH:37][C:36](B3OC(C)(C)C(C)(C)O3)=[CH:35][CH:34]=2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[C:49](Cl)(=O)[CH:50]=C>>[C:15]([NH:16][C@@H:17]1[CH2:18][CH2:19][C@H:20]([NH:23][C:7]2[C:2]([C:36]3[CH:37]=[CH:38][C:33]([C:32]([NH:31][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[O:48])=[CH:34][CH:35]=3)=[C:3]([NH2:9])[N:4]=[CH:5][N:6]=2)[CH2:21][CH2:22]1)(=[O:24])[CH:49]=[CH2:50]

Participants

5

Reactant 4

HCID 13140Acryloyl chlorideHCID 242192625,6-Dichloro-pyrimidin-4-ylamineHCID 57415689N-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamideHCID 178418966HCID 178418966, compound

Product 1

HCID 178460243HCID 178460243, compound

Procedure

4-(4-((cis-4-acrylamidocyclohexyl)amino)-6-aminopyrimidin-5-yl)-N-phenylbenzamide was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl-(cis-4-aminocyclohexyl)carbamate, N-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, and acryloyl chloride using methods B, C, D, and E. HPLC: 100%. MS: m/z=457 [M+H]+.

Sources & evidence

ORD record
ord-4f935f5794dd4f629aaaa84422aeac88
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

Loading…