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HRID1522232

反应详情

EQUATION

反应方程式

HRID 1522232 的结构方程式

REACTANTS

反应物

4
结构：C=CC(=O)Cl
HCID13140

Acrylyl chloride

C3H3ClO

结构：CC(C)(C)OC(=O)N1CCC(CN)CC1
HCID736817

1-Boc-4-(aminomethyl)piperidine

C11H22N2O2

结构：CC1(C)OB(c2ccc(Oc3ccccc3)nc2)OC1(C)C
HCID22346720

2-Phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

C17H20BNO3

结构：Nc1ncnc(Cl)c1Cl
HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

PRODUCTS

生成物

1
结构：C=CC(=O)N1CCC(CNc2ncnc(N)c2-c2ccc(Oc3ccccc3)nc2)CC1
HCID86721818

未命名化合物

PROCEDURE

实验过程

1-(4-(((6-amino-5-(6-phenoxypyridin-3-yl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, 2-phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, and acryloyl chloride using methods B, C, D, and F. HPLC: 100%. MS: m/z=431 [M+H]+.