HRID1522255

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11568

3-Aminophenol

C6H7NO

HCID13140

Acrylyl chloride

C3H3ClO

HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

结构：CC1(C)OB(c2cnn(Cc3cccc(C(F)(F)F)c3)c2)OC1(C)C

HCID71092990

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazole

C17H20BF3N2O2

PRODUCTS

生成物

结构：C=CC(=O)Nc1cccc(Oc2ncnc(N)c2-c2cnn(Cc3cccc(C(F)(F)F)c3)c2)c1

HCID71473852

未命名化合物

PROCEDURE

实验过程

N-(3-((6-amino-5-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)oxy)phenyl)acrylamide was prepared from 5,6-dichloropyrimidin-4-amine, 3-aminophenol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(3-(trifluoromethyl)benzyl)-1H-pyrazole, and acryloyl chloride using methods A, C, and F. HPLC: 98%. MS: m/z=481 [M+H]+. 1H-NMR (DMSO-d6) δ 10.20 (s, 1H), 8.20 (s, 1H), 8.00 (s, 1H), 7.75-7.29 (m, 8H), 6.93-6.58 (m, 3H), 6.42 (dd, 1H), 6.25 (d, 1H), 5.77 (d, 1H), 5.49 (s, 2H).