HRID1522258

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11568

3-Aminophenol

C6H7NO

HCID13140

Acrylyl chloride

C3H3ClO

HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

结构：COc1cccc(Cn2cc(B3OC(C)(C)C(C)(C)O3)cn2)c1

HCID86721840

1-[(3-Methoxyphenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C17H23BN2O3

PRODUCTS

生成物

结构：C=CC(=O)Nc1cccc(Oc2ncnc(N)c2-c2cnn(Cc3cccc(OC)c3)c2)c1

HCID86721839

未命名化合物

PROCEDURE

实验过程

N-(3-((6-amino-5-(1-(3-methoxybenzyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)oxy)phenyl)acrylamide was prepared from 5,6-dichloropyrimidin-4-amine, 3-aminophenol, 1-(3-methoxybenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, and acryloyl chloride using methods A, C, and F. HPLC: 99%. MS: m/z=443 [M+H]+. 1H-NMR (DMSO-d6) δ 10.20 (s, 1H), 8.13 (s, 1H), 7.99 (s, 1H), 7.72 (s, 1H), 7.49 (s, 1H), 7.41 (d, 1H), 7.33-7.23 (m, 2H), 6.87-6.79 (m, 4H), 6.63 (broad s, 2H), 6.42 (dd, 1H), 6.25 (d, 1H), 5.76 (d, 1H), 5.33 (s, 2H), 3.70 (s, 3H).