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HRID1522262

反应详情

EQUATION

反应方程式

HRID 1522262 的结构方程式

REACTANTS

反应物

4
结构：C=CC(=O)Cl
HCID13140

Acrylyl chloride

C3H3ClO

结构：CC1(C)OB(c2ccc(Oc3ccc(C#N)cc3)cc2)OC1(C)C
HCID22346889

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]benzonitrile

C19H20BNO3

结构：Nc1ncnc(Cl)c1Cl
HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

结构：CC(C)(C)OC(=O)N1CC2(CC(O)C2)C1
HCID52987765

tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

C11H19NO3

PRODUCTS

生成物

1
结构：C=CC(=O)N1CC2(CC(Oc3ncnc(N)c3-c3ccc(Oc4ccc(C#N)cc4)cc3)C2)C1
HCID86721842

未命名化合物

PROCEDURE

实验过程

4-(4-(4-((2-acryloyl-2-azaspiro[3.3]heptan-6-yl)oxy)-6-aminopyrimidin-5-yl)phenoxy)benzonitrile was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate, 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile, and acryloyl chloride using methods A, C, D, and F. HPLC: 100%. MS: m/z=454 [M+H]+.