HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acryloyl chloride → HCID 86721847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]benzonitrile | HCID 22346889 | — |
| Reactant | 5-Bromo-6-chloropyrimidin-4-amine | HCID 45789713 | — |
| Reactant | Tert-butyl 3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate | HCID 53487663 | — |
| Product | HCID 86721847 | HCID 86721847 | — |
Reaction Steps
4-(4-(4-(((8-acryloyl-8-azabicyclo[3.2.1]octan-3-ylmethyl)amino)-6-aminopyrimidin-5-yl)phenoxy)benzonitrile was prepared from 5-bromo-6-chloropyrimidin-4-amine, tert-butyl 3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate, 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile, and acryloyl chloride using methods B, C, D, and F. HPLC: 98%. MS: m/z=481 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073947B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-c761a27bb9534a728d3c306c94a80353 |
| Source note | uspto-grants-2015_07 |