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HRID1522269

反应详情

EQUATION

反应方程式

HRID 1522269 的结构方程式

REACTANTS

反应物

4
结构：C=CC(=O)Cl
HCID13140

Acrylyl chloride

C3H3ClO

结构：CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C
HCID2734771

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C16H21BN2O2

结构：Nc1ncnc(Cl)c1Br
HCID45789713

5-Bromo-6-chloropyrimidin-4-amine

C4H3BrClN3

结构：CC(C)(C)OC(=O)N1C2CCC1CC(CN)C2
HCID53487663

未命名化合物

PRODUCTS

生成物

1
结构：C=CC(=O)N1C2CCC1CC(CNc1ncnc(N)c1-c1cnn(Cc3ccccc3)c1)C2
HCID86721848

未命名化合物

PROCEDURE

实验过程

1-(3-(((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)methyl)-8-azabicyclo[3.2.1]octan-8-yl)prop-2-en-1-one was prepared from 5-bromo-6-chloropyrimidin-4-amine, tert-butyl 3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate, 1-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, and acryloyl chloride using methods B, C, D, and F. HPLC: 99%. MS: m/z=444 [M+H]+.