huagongshe.com
HRID1522291

反应详情

EQUATION

反应方程式

HRID 1522291 的结构方程式

REACTANTS

反应物

2
结构：CN(C)C/C=C/C(=O)O.Cl
HCID45358758

(2E)-4-(Dimethylamino)but-2-enoic acid hydrogenchloride

C6H12ClNO2

结构：Nc1cccc(-c2c(N)ncnc2Oc2ccc(Oc3ccccc3)cc2)c1
HCID71474012

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C/C=C/C(=O)Nc1cccc(-c2c(N)ncnc2Oc2ccc(Oc3ccccc3)cc2)c1
HCID71092974

未命名化合物

收率 26%

PROCEDURE

实验过程

(E)-N-(3-(4-amino-6-(4-phenoxyphenoxy)pyrimidin-5-yl)phenyl)-4-(dimethylamino)but-2-enamide was prepared from 5-(3-aminophenyl)-6-(4-phenoxyphenoxy)pyrimidin-4-amine and (E)-4-(dimethylamino)but-2-enoic acid hydrochloride using Method E (26% yield). HPLC: 97%, RT=3.608 min. MS: m/z=482 [M+H]+, RT=3.57 min. 1H-NMR (DMSO-d6), δ 10.33 (s, 1H), 9.66 (s, 1H), 8.01 (s, 1H), 7.66-7.64 (m, 2H), 7.38 (t, 1H), 7.32 (t, 2H), 7.11-6.92 (m, 8H), 6.68 (m, 1H), 6.41 (m, 3H), 3.88 (m, 2H), 2.73 (s, 6H).