HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-4-morpholinobut-2-enoic acid → (E)-N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)phenyl)-4-morpholinobut-2-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-4-morpholinobut-2-enoic acid | HCID 22466617 | — |
| Reactant | 6-(3-Aminophenoxy)-5-(4-phenoxyphenyl)pyrimidin-4-amine | HCID 86721735 | — |
| Product | (E)-N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)phenyl)-4-morpholinobut-2-enamide | HCID 71092946 | 19% |
Reaction Steps
(E)-N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)phenyl)-4-morpholinobut-2-enamide was prepared from 6-(3-aminophenoxy)-5-(4-phenoxyphenyl)pyrimidin-4-amine and (E)-4-morpholinobut-2-enoic acid using Method E (19% yield). HPLC: 100%, RT=3.605 min. MS: m/z=524 [M+H]+, RT=3.59 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073947B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-1e2256319aad4b1a8c46dc8d1ed87be3 |
| Source note | uspto-grants-2015_07 |