Aniline → Maleic acid anilide

HRID 1522320Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]1(=[O:14])[O:13][C:11](=[O:12])[CH:10]=[CH:9]1>>[C:2]1([NH:1][C:8](=[O:14])/[CH:9]=[CH:10]\[C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6115Aniline

HCID 7923Maleic Anhydride

Product 1

HCID 1550938Maleic acid anilide

Procedure

Aniline (1 mol) and maleic anhydride (1.0 mol) were subjected to an addition reaction at 20 to 30° C. for 2.5 hours to give N-phenylmaleamidic acid. Then, the resulting N-phenylmaleamidic acid was neutralized with sodium hydroxide under cooling to give an N-phenylmaleamidic acid sodium salt.

Sources & evidence

ORD record: ord-d7ae92aa142649d2914dac06ca78edb4
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09074063B2

Reaction notes

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