1-(1-Methylethyl)-6-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid → 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-phenyl-1,2-dihydro-3-pyridinyl)methyl]-6-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared in the same manner as described in example 11 from 1-(1-methylethyl)-6-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (150 mg, 0.531 mmol) and 3-(aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone (133 mg, 0.531 mmol). The product was collected as a white solid, 0.041 g (15%). LCMS E-S (M+H)=479.3. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.57 (d, J=6.82 Hz, 6 H) 2.23 (s, 3 H) 4.23-4.27 (m, 2 H) 5.33-5.42 (m, 1 H) 6.02-6.04 (m, 1 H) 7.35-7.42 (m, 1 H) 7.43 (s, 4 H) 8.23-8.26 (m, 1 H) 8.34-8.39 (m, 2 H) 8.41-8.42 (m, 1 H) 8.84-8.88 (m, 2 H) 8.91-8.96 (m, 1 H) 11.91 (s, 1 H).

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