反应详情

The title compound was prepared in the same manner as described for intermediate 64 using ethyl 2,4-dioxo-4-(4-pyridinyl)butanoate (766 mg, 2.87 mmol), benzene (6 mL), and 3-methyl-1-(1-methylethyl)-1H-pyrazol-5-amine (400 mg, 2.87 mmol). The crude product was purified using column chromatography (Silica gel, eluent: 0 to 30% MeOH/DCM) to give 95 mg (10%) of product. LCMS E-S (M+H)=325.3. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.48-1.56 (m, 3 H), 1.61-1.73 (m, 6 H), 2.77 (s, 3 H), 4.56 (q, J=7.2 Hz, 2 H), 5.37-5.50 (m, 1 H), 8.02-8.16 (m, 3 H), 8.76-8.83 (m, 2 H).

1. customThe crude product was purified