1,2-Dichloroethane → HCID 68078819, compound

Participants

Reaction Steps

The title compound was prepared in the same manner as described in example 121 using 1-(1,1-dimethylethyl)-3-methyl-6-[3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (58 mg, 0.167 mmol), 3-(aminomethyl)-4,6-dimethyl-2(1H)-pyridinone (47 mg, 0.251 mmol), N-methylmorpholine (0.092 mL, 0.836 mmol), 1-hydroxy-7-azabenzotriazole (46 mg, 0.334 mmol), EDC (64 mg, 0.334 mmol), and DMSO (1 mL). The product was collected as 73 mg (96%). LCMS E-S (M+H)=445.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.81 (s, 9 H), 2.12 (s, 3 H), 2.25 (s, 3 H), 2.42 (s, 3 H), 4.39 (d, J=5.05 Hz, 2 H), 5.89 (s, 1 H), 7.59 (dd, J=8.08, 4.80 Hz, 1 H), 7.78 (s, 1 H), 8.55 (dt, J=8.15, 1.86 Hz, 1 H), 8.68 (dd, J=4.80, 1.52 Hz, 1 H), 8.74 (t, J=5.05 Hz, 1 H) 9.38 (d, J=1.77 Hz, 1 H), 11.54 (s,1 H).

Provenance & Evidence