Ethyl 4-cyclopropyl-2,4-dioxobutanoate → HCID 89444869, compound

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Reaction Steps

1-cyclopropyl-3-methyl-1H-pyrazol-5-amine (300 mg, 2.187 mmol), ethyl 4-cyclopropyl-2,4-dioxobutanoate (403 mg, 2.187 mmol) and acetic Acid (40 mL) were heated at reflux for 2 hours. The solvent was removed in vacuo and the crude residue was purified via silica gel chromatography (eluent: 0 to 11% EtOAc:Hex). The product was collected as 310 mg. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.05-1.13 (m, 4 H), 1.16-1.21 (m, 2 H), 1.25-1.30 (m, 2 H), 1.46 (t, J=7.20 Hz, 3 H), 2.16-2.31 (m, 1 H), 2.63 (s, 3 H), 3.78 (m, J=7.26, 7.26, 3.79, 3.66 Hz, 1 H), 4.47 (q, J=7.24 Hz, 2 H), 7.40 (s, 1 H). LCMS(ES) [M+H]+ 286.2

Provenance & Evidence