Methylhydrazine → 3'-Fluoro-6'-methyl-2,2'-bipyridin-4-amine

Participants

Reaction Steps

2-(3′-fluoro-6′-methyl-2,2′-bipyridin-4-yl)isoindoline-1,3-dione (65 mg, 0.195 mmol) was suspended in dichloromethane (3 mL); methylhydrazine (0.205 mL, 3.90 mmol) was added and the mixture was stirred at room temperature over night. The reaction was filtered thru Celite® and the filtrate was concentrated to give the title compound as a clear yellow film which was used without further purification. ESI-MS: m/z 204.1 (M+H).

Provenance & Evidence