Hydrochloric Acid → 2-(5-Chloro-2-fluorophenyl)-6-methylisonicotinic acid

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(5-chloro-2-fluorophenyl)-6-methylisonicotinate (1.86 g, 6.65 mmol) was dissolved in methanol (24 mL) and NaOH (16.6 ml, 33.3 mmol) was added. The reaction was heated at 60° C. for 1.5 hour, cooled to room temperature, acidified (pH˜2) with 6N HCl to give a precipitate which was filtered and dried to give 2-(5-chloro-2-fluorophenyl)-6-methylisonicotinic acid (1.17 g) as a off white solid which was used without further purification. ESI-MS: m/z 266.1 (M+H).

Provenance & Evidence