Hydrochloric Acid → HCID 67469678, compound

Participants

Reaction Steps

To a solution of N-acetyl-N-(4-bromo-2-methylpyridin-3-yl)acetamide (0.95 g, 3.50 mmol) in methanol (14.02 mL) was added 1M NaOH (0.876 ml, 0.876 mmol) and the reaction was stirred at room temperature for 30 minutes. The reaction mixture was neutralized with 1N HCl (400 uL) and then concentrated under vacuum to give a residue that was purified on silica column chromatography eluting with (chloroform:methanol, 97:3) Concentration of the product fractions gave N-(4-bromo-2-methylpyridin-3-yl)acetamide (0.7 g, 3.06 mmol, 87% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.04-2.10 (m, 3H) 2.39 (s, 3H) 7.49-7.60 (m, 1H) 8.12-8.26 (m, 1H) 9.65-9.83 (m, 1H). MS [M+H] found 229.1.

Provenance & Evidence