Sodium hydride → 2-(7-chloro-6-fluoro-2H-pyrazolo[4,3-b]pyridin-2-yl)-N-methylacetamide

Participants

Reaction Steps

7-Chloro-6-fluoro-1H-pyrazolo[4,3-b]pyridine (100 mg, 0.583 mmol) and NaH (28.0 mg, 60% in oil, 0.699 mmol) in THF (2.0 mL) was stirred at 0° C. for 15 minutes. 2-Bromo-N-methylacetamide (89 mg, 0.583 mmol) was added and the reaction was allowed to warm to room temperature for 12 hours. The reaction mixture was then concentrated in vacuo to give 2-(7-chloro-6-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N-methylacetamide and 2-(7-chloro-6-fluoro-2H-pyrazolo[4,3-b]pyridin-2-yl)-N-methylacetamide which were used without further purification.

Provenance & Evidence