反应详情

To a solution of (3-methoxy-4-methylphenyl)methanol (2.0 g, 13.0 mmol) in dry DCM (20 mL) at 0° C., SOCl2 (3.1 g, 26.0 mmol) was added slowly. The resulting solution was stirred at room temperature for 0.5 h. The mixture was evaporated, and the residue was dissolved in DCM (20 mL). The mixture was washed with saturated NaHCO3 (3×10 mL), dried over Na2SO4 and evaporated to give the title compound as brown oil (2.1 g).

1. customThe mixture was evaporated
2. dissolutionthe residue was dissolved in DCM (20 mL)
3. washThe mixture was washed with saturated NaHCO3 (3×10 mL)
4. dry with materialdried over Na2SO4
5. customevaporated